Research at the Institute
The research carried out at the Institute of Experimental Biology focuses on the processes and phenomena involved in the organisation and functioning of living cells, tissues and organisms. The model systems studied are viral, microbial, plant, animal and human systems, which are investigated using a variety of approaches from contemporary molecular biology, genetics, genomics, proteomics, gene and protein engineering, physiology, biochemistry, analytical chemistry, electrochemistry, biophysics, etc. In addition to basic research, the Institute of Experimental Biology also carries out applied research, contributing to our understanding of the nature of certain genetic and infectious diseases in humans and to improving their diagnosis, or to the development of new biotechnological processes.
Teams with similar teaching and research focuses form the individual departments of the Institute. Their main research activities focus on molecular diagnostics and the taxonomy of microorganisms, molecular cytogenetics, molecular and stress biology of plants, tumour biology and genetics, molecular anthropology, environmental microbiology, microbial biotechnology, stress physiology of plants, cellular and molecular physiology of human and animal systems, and enzyme engineering. The wide range of methods employed and the diversity of the subjects studied provide a solid foundation for the scientific training of students and ensure their strong employability in the labour market.
Research Laboratories
Individual laboratories and research groups are organised into departments, which, through their scientific and teaching work, specialise in specific fields of experimental biology.
Projects
Total number of projects: 67
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Nalezení nových terapeutických cílů pro léčbu obrovskobuněčného kostního nádoru (NU22-10-00054)
MU Researcher: doc. RNDr. Jakub Neradil, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 5/2022 — 12/2026Investor: Ministry of Health of the CR / Programme NU (2020 - 2026) -
DIOSCURI Centre for Stem Cell Biology and Metabolic Diseases (LV23007)
MU Researcher: Mgr. Peter Fabian, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 7/2024 — 6/2029Investor: Ministry of Education, Youth and Sports of the CR / DIOSCURI -
DIOSCURI Centre for Stem Cell Biology and Metabolic Diseases - dofinancování (MUNI/DC/1077/2024)
MU Researcher: Mgr. Peter Fabian, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 7/2024 — 6/2029Investor: Masaryk University / Grant Agency of Masaryk University -
Macrophage-derived extracellular vesicles as immunomodulatory agents in intestinal inflammation (MUNI/C/0132/2025)
MU Researcher: Bc. Júlia Orlovská MU Faculty or unit: Faculty of Science Project Period: 3/2025 — 2/2026Investor: Masaryk University / Grant Agency of Masaryk University -
Podpora výzkumné práce studentů experimentální biologie rostlin 2026 (MUNI/A/1717/2025)
MU Researcher: doc. RNDr. Vít Gloser, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2026 — 12/2026Investor: Masaryk University / Specific research - support for student projects -
Decoding maternal immunity and fetal vulnerability in TBEV vaccination and flavivirus infection (101272098)
MU Researcher: Mgr. Jiří Holoubek, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 11/2026 — 10/2028Investor: European Union / Horizon Europe -
Integrace nástrojů umělé inteligence do výuky předmětů Bi5610 a Bi5610en: rozvoj digitálních kompetencí biologa (MUNI/AI-I/1025/2026)
MU Researcher: doc. RNDr. Pavel Hyršl, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 7/2026 — 6/2027Investor: Masaryk University / Individual support for the use of AI in teaching -
A molecular roadmap for the emergence of air breathing (MUNI/31/HFSP2025)
MU Researcher: Mgr. Peter Fabian, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 7/2025 — 6/2028Investor: Human Frontier Science Program Organization / Research Grants -
A new strategy for the assembly of biocatalytic scaffolds on bacterial surface for facilitated processing of polymeric waste (GA25-16845S)
MU Researcher: doc. Mgr. Pavel Dvořák, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 1/2025 — 12/2027Investor: Czech Science Foundation / Standard Projects -
Ancient dental calculus as a tool of anthropology and paleogenetics (MUNI/R/1413/2024)
MU Researcher: Mgr. Dana Buriánková Fialová, Ph.D. MU Faculty or unit: Faculty of Science Project Period: 2/2025 — 12/2026Investor: Masaryk University / Grant Agency of Masaryk University
Publications
Total number of publications: 106
Articles
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A Wnt-induced conformational phospho-switch in DVL3 controls association with Frizzled receptors and Wnt/β-catenin signaling
SCIENCE ADVANCES, year: 2026, volume: 12, edition: 20, DOI
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Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2-COL3A1 axis
Molecular Oncology, year: 2026, volume: 20, edition: 8, DOI
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AI Assistance Reduces Missed Fractures on Musculoskeletal Radiographs: A Multicentre Multi-Reader Crossover Study
European Journal of Radiology Artificial Intelligence, year: 2026, volume: 7, DOI
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Aicardi-Goutieres Syndrome Type 6: Case Report and Structural Prediction Supporting a Dominant-Negative Effect of the ADAR1 c.3019G>A Variant
CLINICAL CASE REPORTS, year: 2026, volume: 14, edition: 4, DOI
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Antimicrobial resistance in veterinary medicine: Mechanisms, regulation and control strategies
Veterinarni Medicina, year: 2026, volume: 71, edition: 6, DOI
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Assessment of obstetric analgesia in the Czech Republic and Slovak Republic-international study 2022
JOURNAL OF ANESTHESIA ANALGESIA AND CRITICAL CARE, year: 2026, volume: 6, edition: 1, DOI
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Associations of Lifestyle Factors with Cadmium and Nickel in Seminal Fluid of Potential Sperm Donors
BIOLOGICAL TRACE ELEMENT RESEARCH, year: 2026, DOI
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Bacterial supplementation shapes honey bee gut microbiota and host metabolism under controlled and field conditions
MSYSTEMS, year: 2026, volume: 11, edition: 6, DOI
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Bacteriome-based oral dysbiosis index in patients with oral squamous cell carcinoma
JOURNAL OF ORAL MICROBIOLOGY, year: 2026, volume: 18, edition: 1, DOI
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Beyond the genome: alternative splicing as a key driver of cellular plasticity and clinical heterogeneity in pancreatic cancer.
CLINICAL AND EXPERIMENTAL MEDICINE, year: 2026, DOI